Seven Mathematical Models of Hemorrhagic Shock

Autor: Andrea De Gaetano, Laura D'Orsi, Luciano Curcio
Přispěvatelé: Curcio, Luciano, D'Orsi, Laura, De Gaetano, Andrea
Rok vydání: 2021
Předmět:
Systems Analysis
Computer science
Respiratory System
Computer applications to medicine. Medical informatics
0206 medical engineering
R858-859.7
Blood Pressure
Review Article
02 engineering and technology
Shock
Hemorrhagic
030204 cardiovascular system & hematology
Key issues
Cardiovascular System
Settore ING-INF/01 - Elettronica
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Hemorrhagic Shock
Humans
Computer Simulation
Vascular hemodynamics
Settore MAT/07 - Fisica Matematica
General Immunology and Microbiology
Mathematical model
Management science
Applied Mathematics
Scale (chemistry)
Hemodynamics
Models
Cardiovascular
Computational Biology
Mathematical Concepts
General Medicine
020601 biomedical engineering
Biomechanical Phenomena
Cardiovascular model
Modeling and Simulation
Settore ING-INF/06 - Bioingegneria Elettronica E Informatica
Hemorrhagic shock
Cardiovascular dynamics
mathematical model
Zdroj: Computational and Mathematical Methods in Medicine, Vol 2021 (2021)
Computational and Mathematical Methods in Medicine
Computational and mathematical methods in medicine
2021 (2021). doi:10.1155/2021/6640638
info:cnr-pdr/source/autori:Curcio Luciano; D'Orsi Laura; De Gaetano Andrea/titolo:Seven Mathematical Models of Hemorrhagic Shock/doi:10.1155%2F2021%2F6640638/rivista:Computational and mathematical methods in medicine (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:2021
ISSN: 1748-6718
1748-670X
DOI: 10.1155/2021/6640638
Popis: Although mathematical modelling of pressure-flow dynamics in the cardiocirculatory system has a lengthy history, readily finding the appropriate model for the experimental situation at hand is often a challenge in and of itself. An ideal model would be relatively easy to use and reliable, besides being ethically acceptable. Furthermore, it would address the pathogenic features of the cardiovascular disease that one seeks to investigate. No universally valid model has been identified, even though a host of models have been developed. The object of this review is to describe several of the most relevant mathematical models of the cardiovascular system: the physiological features of circulatory dynamics are explained, and their mathematical formulations are compared. The focus is on the whole-body scale mathematical models that portray the subject’s responses to hypovolemic shock. The models contained in this review differ from one another, both in the mathematical methodology adopted and in the physiological or pathological aspects described. Each model, in fact, mimics different aspects of cardiocirculatory physiology and pathophysiology to varying degrees: some of these models are geared to better understand the mechanisms of vascular hemodynamics, whereas others focus more on disease states so as to develop therapeutic standards of care or to test novel approaches. We will elucidate key issues involved in the modeling of cardiovascular system and its control by reviewing seven of these models developed to address these specific purposes.
Databáze: OpenAIRE
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