Comprehensive non-invasive assessment of electrocardiographic abnormalities and cardiac arrhythmias in patients with genetically confirmed mitochondrial diseases
| Autor: | Biruta Kierdaszuk, Olga Zdończyk, Mateusz Jermakow, Piotr Bienias, Agnieszka Miroszewska, Anna Kostera-Pruszczyk, Magdalena Kaliszewska, Anna Maria Gawałkiewicz, Marta Jaworska, Piotr Pruszczyk |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Mitochondrial Diseases Mitochondrial disease 030204 cardiovascular system & hematology QT interval Electrocardiography 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Repolarization In patient cardiovascular diseases 030212 general & internal medicine Aged medicine.diagnostic_test business.industry Non invasive Arrhythmias Cardiac Middle Aged Intraventricular conduction medicine.disease cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business Atrioventricular block |
| Zdroj: | Journal of Electrocardiology. 65:136-142 |
| ISSN: | 0022-0736 |
| DOI: | 10.1016/j.jelectrocard.2021.01.021 |
| Popis: | There is limited data on cardiac arrhythmias and ventricular repolarization and dispersion abnormalities in patients with mitochondrial diseases (MitD).Consecutive 40 patients with genetically proven MitD and 35 healthy controls were studied. Among other examinations all subjects underwent 24-h Holter recording and 12‑lead electrocardiography (ECG) with corrected QT (QTc), QT dispersion (QTd), Tp-e and Tp-e/QT ratio assessment.Patients with MitD were 55.4 ± 15.7 years old, the disease duration was 18.5 ± 10.3 years, presented 6 clinical syndromes while mitochondrial and nuclear DNA type of mutation was present in 40 and 60% of cases, respectively. In MitD more frequently 1st degree atrioventricular block and intraventricular conduction defects were observed and also QRS complex duration was increased. Mean values of QTc (p = 0.001), QTd (p = 0.02), Tp-e (p 0.00001) and Tp-e/QT (p 0.00001) were significantly higher in MitD than in controls. Correlations between disease duration and PR interval duration (p = 0.003) and Creatine Kinase MB isoenzyme activity (p = 0.02) were found. No differences in depolarization and dispersion parameters were observed according to type of mutation or dominant clinical syndromes. In addition to supraventricular extrasystoles, nonsustained supraventricular tachycardias occurred more frequently in MitD (in 45.0 vs 14.3%, p = 0.0004). Ventricular arrhythmias were rare and observed almost exclusively in subjects with mitochondrial DNA mutation.In contrast to healthy controls, in MitD patients intraventricular, repolarization and dispersion disturbances were more frequently observed. In addition to bradyarrhythmias observed in some defined MitD syndromes, supraventricular rather than ventricular arrhythmias are more common. |
| Databáze: | OpenAIRE |
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