A novel optinEuRin stress connection in glaucoma

Autor: Elodie Lafont, Tony Avril
Přispěvatelé: Oncogenesis, Stress, Signaling (OSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Eugène Marquis (CRLCC), Institut National de la Santé et de la Recherche Médicale, Ligue Contre le Cancer, Région Bretagne, Université de Rennes 1
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: FEBS Journal
FEBS Journal, 2023, ⟨10.1111/febs.16774⟩
ISSN: 1742-464X
1742-4658
Popis: International audience; The endoplasmic reticulum (ER) is the organelle where the production and shaping of most secreted and transmembrane proteins happens. ER function is finely regulated to prevent accumulation of misfolded proteins generating ER stress. ER stress is common in both healthy and pathological situations due to multiple intrinsic and extrinsic factors including acute demand in protein synthesis, hypoxia or impaired protein folding caused by gene mutations. Sayyad et al. found that the M98K mutation of optineurin sensitizes glaucoma retinal ganglion cells to ER stress-induced cell death. This is associated with an autophagy-dependent elevation of ER stress sensor expression.
Databáze: OpenAIRE
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