Circular RNAs in the cardiovascular system
| Autor: | Clarissa P.C. Gomes, Yvan Devaux, Esther E. Creemers, Christoph Dieterich, Antonio Salgado-Somoza, Mitja Luštrek |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Artificial intelligence lcsh:QH426-470 Cardiovascular health Computational biology 030204 cardiovascular system & hematology Biology Biochemistry Article Non-coding RNAs RPAD RNase R treatment followed by polyadenylation and poly(A)+ RNA depletion 03 medical and health sciences 0302 clinical medicine Genetics miRNAs microRNAs DCM - Dilated cardiomyopathy RT-qPCR reverse transcription quantitative polymerase chain reaction DCM dilated cardiomyopathy Molecular Biology ncRNAs non-coding RNAs lncRNAs long non-coding RNAs Biochemistry (medical) CV cardiovascular RNA-seq RNA sequencing Biomarker Cardiovascular disease Review article lcsh:Genetics Cardiovascular system 030104 developmental biology CRISPR clustered regularly interspaced short palindromic repeats circRNAs circular RNAs EMT epithelial-mesenchymal transition Circular RNAs |
| Zdroj: | Non-coding RNA Research Non-coding RNA Research, Vol 3, Iss 1, Pp 1-11 (2018) |
| ISSN: | 2468-0540 |
| DOI: | 10.1016/j.ncrna.2018.02.002 |
| Popis: | Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs. Recent investigations showed that circRNAs are regulated in the cardiovascular system and participate in its physiological and pathological development. In this review article, we will provide an overview of the role of circRNAs in cardiovascular health and disease. After a description of the biogenesis of circRNAs, we will summarize what is known of the expression, regulation and function of circRNAs in the cardiovascular system. We will then address some technical aspects of circRNAs research, discussing how artificial intelligence may aid in circRNAs research. Finally, the potential of circRNAs as biomarkers of cardiovascular disease will be addressed and directions for future research will be proposed. Keywords: Non-coding RNAs, Circular RNAs, Cardiovascular system, Cardiovascular disease, Artificial intelligence, Biomarker |
| Databáze: | OpenAIRE |
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