Fecal Calprotectin and Quality of Life Questionnaires Are Responsive to Change in Pouch Disease Activity After Antibiotic Therapy: Results From a Prospective Clinical Trial

Autor:	Jacob E, Ollech, Henit, Yanai, Irit, Avni-Biron, Yifat, Snir, Hagar, Banai, Revital, Barkan, Lihi, Godny, Nir, Wasserberg, Ian, White, Iris, Dotan
Rok vydání:	2022
Předmět:	Hepatology Gastroenterology
Zdroj:	American Journal of Gastroenterology. 118:367-370
ISSN:	1572-0241 0002-9270
DOI:	10.14309/ajg.0000000000002038
Popis:	Whether fecal calprotectin (FC) and quality of life (QoL) questionnaires reflect change in disease activity in patients with a J-pouch is unknown.Patients with acute pouchitis were prospectively treated with a 2-week course of antibiotics. The full Pouchitis Disease Activity Index, FC, and QoL questionnaires were measured at baseline and after antibiotic therapy.Twenty patients were prospectively enrolled. After 2 weeks of antibiotic treatment, the Pouchitis Disease Activity Index decreased from a median of 9 to 5 ( P = 0.007). FC decreased from a median of 661 ug/g to 294 ug/g ( P = 0.02), and QoL questionnaires improved significantly.FC and QoL questionnaires reflect real-time changes in inflammatory pouch activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa09fdeeac15929d51af53400d42486 https://doi.org/10.14309/ajg.0000000000002038 Zobrazit plný text záznamu