Evaluation of Plasma Soluble Urokinase Plasminogen Activator Receptor Levels in Patients With COVID-19 and Non-COVID-19 Pneumonia: An Observational Cohort Study
| Autor: | Konstantinos Tsiotsios, Nikolaos Pantzaris, Sofia Karteri, Dimitrios Velissaris, Themistoklis Paraskevas, Vasileios Karamouzos, Eleousa Oikonomou, Markos Marangos, Maria Lagadinou, Dimitrios Bousis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry COVID-19 Inflammation Biomarker General Medicine Prognosis medicine.disease Gastroenterology suPAR Pneumonia SuPAR Fraction of inspired oxygen Internal medicine Medicine Biomarker (medicine) Original Article Respiratory system medicine.symptom business Receptor Chest infection Cohort study |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr4579 |
| Popis: | Background: The respiratory system is the main system affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and a great number of infected people need hospitalization. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker indicative of acute and chronic inflammation. Current literature supports that suPAR has great predictive ability for mortality in patients with coronavirus disease 2019 (COVID-19). The aim of this study was to compare the value of suPAR and other laboratory biomarkers in patients with chest infection and suspected COVID-19. Methods: A total of 41 consecutive patients with chest infection were enrolled in the study and were assigned into two groups according to the real-time polymerase chain reaction (PCR) result for SARS-CoV-2. The two groups had no significant difference in baseline data (age, sex), arterial oxygen partial pressure (PO 2 )/fraction of inspired oxygen (FiO 2 ) ratio and mortality. Results: Among patients with chest infection who required hospitalization, suPAR was significantly higher on admission in those with COVID-19 when compared to patients with non-COVID-19. suPAR had a great prognostic ability for in-hospital mortality in the COVID-19 subgroup. Conclusions: A single measurement of suPAR on admission can provide prognostic information for patients with suspected COVID-19 pneumonia. In the subgroup of patients with positive real-time PCR result for SARS-CoV2, suPAR was significantly higher and had an excellent prognostic value for the in-hospital mortality. J Clin Med Res. 2021;13(9):474-478 doi: https://doi.org/10.14740/jocmr4579 |
| Databáze: | OpenAIRE |
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