In Vivo Function of the ER-Golgi Transport Protein LMAN1 in Photoreceptor Homeostasis
| Autor: | Yichao Li, Haohua Qian, Bin Zhang, Janina Gregorski, Hong Hao, Chun Y Gao, Sana Idrees |
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| Rok vydání: | 2014 |
| Předmět: |
genetic structures
Golgi Apparatus Endoplasmic Reticulum Article Mice symbols.namesake In vivo medicine Animals Homeostasis Transcription factor Mice Knockout Retina biology Membrane Proteins Biological Transport Golgi apparatus eye diseases Transmembrane protein Transport protein Cell biology Mannose-Binding Lectins medicine.anatomical_structure Rhodopsin biology.protein symbols sense organs Photoreceptor Cells Vertebrate |
| Zdroj: | Retinal Degenerative Diseases ISBN: 9781461432081 |
| Popis: | LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1 (- / -) mouse eyes did not show abnormality in histology and electroretinogram analysis at 3 months, Lman1 (- / -) retina at 6 months showed a decrease in cis-Golgi markers GM130 and GRASP65. We also observed abnormal level and location of Rhodopsin in these mice. Taken together, LMAN1 may play a role in photoreceptor gene transport and homeostasis. |
| Databáze: | OpenAIRE |
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