Long-term follow-up of childhood Henoch-Schönlein nephritis
| Autor: | Cyril Chantler, Amanda R. Goldstein, Rosamund Akuse, Richard H. R. White |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Time Factors IgA Vasculitis Long term follow up Biopsy Remission Spontaneous Disease urologic and male genital diseases Kidney Gastroenterology Impaired renal function Internal medicine medicine Humans Henoch-Schonlein nephritis Child Pregnancy Proteinuria Nephritis medicine.diagnostic_test business.industry General Medicine medicine.disease Surgery Creatinine Female Renal biopsy medicine.symptom business Follow-Up Studies |
| Zdroj: | Lancet (London, England). 339(8788) |
| ISSN: | 0140-6736 |
| Popis: | A study of long-term outcome of 78 subjects who had had Henoch-Schonlein nephritis during childhood (at a mean of 23.4 years after onset) shows that severity of clinical presentation and initial findings on renal biopsy correlate well with outcome but have poor predictive value in individuals. 44% of patients who had nephritic, nephrotic, or nephritic/nephrotic syndromes at onset have hypertension or impaired renal function, whereas 82% of those who presented with haematuria (with or without proteinuria) are normal. 17 patients deteriorated clinically from an initial assessment in 1971; 7 of these had apparently completely recovered in 1976. 16 of 44 full-term pregnancies were complicated by proteinuria and/or hypertension, even in the absence of active renal disease. These findings indicate that childhood Henoch-Schonlein nephritis requires long-term follow-up, especially during pregnancy. |
| Databáze: | OpenAIRE |
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