Impaired lymphocyte reconstitution after autologous transplant is associated with apoptosis of CD8+ T cells and adverse clinical outcome

Autor:	Margalit Bleiberg, Alexey Fourman, Moshe Yeshurun, Boris Tartakovsky, Eti Zigman-Hoffman, Uri Rozovski, Svetlana Trestman, Shani Frank, Ella Naparstek
Rok vydání:	2019
Předmět:	Adult Male Cancer Research Time Factors Lymphocyte medicine.medical_treatment Epitopes T-Lymphocyte Apoptosis Kaplan-Meier Estimate Hematopoietic stem cell transplantation CD8-Positive T-Lymphocytes Risk Assessment Transplantation Autologous Disease-Free Survival Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Lymphopenia Humans Medicine Cytotoxic T cell Lymphocyte Count Autologous transplant Aged business.industry Lymphoma Non-Hodgkin Hematopoietic Stem Cell Transplantation Hematology Middle Aged Prognosis Hodgkin Disease surgical procedures operative medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunology Female Multiple Myeloma business Follow-Up Studies 030215 immunology
Zdroj:	Leukemia & Lymphoma. 60:2264-2270
ISSN:	1029-2403 1042-8194
DOI:	10.1080/10428194.2018.1563696
Popis:	We noticed that the lymphocyte counts, after autologous hematopoietic stem cell transplantation, oscillated during the first 4 post-transplant months. Thereafter, the lymphocyte counts stabilized and segregated the patients into two groups, those who normalized their lymphocyte counts and those with prolonged lymphopenia. In both groups, the CD4 counts remained low for at least 6 months. However, in approximately half of the patient, the CD8 counts increased to normal or above normal values. Patients with prolonged lymphopenia had higher rates of lymphocytes' spontaneous apoptosis and the lymphocytes in patients who restored their counts expressed the intracellular CD14-derived MO2 epitope that protects the cells from apoptosis. These findings were translated to longer disease-free survival and overall survival in patients who restored the CD8 counts. Collectively, our data show that post-transplant lymphocytes that express intracellular CD14-MO2 epitope have survival advantage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9c06d42c457495a1b29e762db575ee https://doi.org/10.1080/10428194.2018.1563696 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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