NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury
| Autor: | Qingnian Goh, Sia Nikolaou, Liangjun Hu, Kritton Shay-Winkler, Roger Cornwall, Brendan L Ho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
muscle atrophy
ErbB Muscle Development Biochemistry neuregulin Muscle hypertrophy Mice Structural Biology Medicine Denervation 0303 health sciences Molecular Basis of Disease 030302 biochemistry & molecular biology Muscle atrophy Muscle Denervation ErbB Receptors Muscular Atrophy medicine.anatomical_structure Neuregulin medicine.symptom muscle growth Signal Transduction medicine.medical_specialty Contracture Morpholines Neuregulin-1 Biophysics Neuromuscular Junction 03 medical and health sciences neonatal brachial plexus injury Internal medicine Genetics Research Letter Animals Brachial Plexus Muscle Skeletal Molecular Biology 030304 developmental biology Muscle contracture denervation business.industry Skeletal muscle Cell Biology Research Letters Endocrinology Animals Newborn Gene Expression Regulation business neuromuscular contractures |
| Zdroj: | Febs Letters |
| ISSN: | 1873-3468 0014-5793 |
| Popis: | Neonatal brachial plexus injury (NBPI) causes disabling and incurable muscle contractures that are driven by impaired growth of denervated muscles. A rare form of NBPI, which maintains afferent muscle innervation despite motor denervation, does not cause contractures. As afferent innervation regulates various aspects of skeletal muscle homeostasis through NRG/ErbB signaling, our current study investigated the role of this pathway in modulating contracture development. Through pharmacologic modification with an ErbB antagonist and NRG1 isoforms, we discovered that NRG/ErbB signaling does not modulate the development of contractures in neonatal mice. Instead, ErbB inhibition impeded growth in nondenervated skeletal muscles, whereas increased ErbB activation exacerbated denervation-induced skeletal muscle atrophy. This potential regulatory effect of NRG/ErbB signaling on neonatal muscle growth warrants deeper investigation. |
| Databáze: | OpenAIRE |
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