A comparison of manual tracing and FreeSurfer for estimating hippocampal volume over the adult lifespan
| Autor: | Thomas H. Mosley, Judd M. Storrs, Michael Griswold, Kevin B. Freeman, Mike F. Schmidt, Stephen T. Turner, Clifford R. Jack |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Computer science Longevity Tracing Hippocampus Functional Laterality Article 03 medical and health sciences Mri image 0302 clinical medicine Atrophy Region of interest Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Aged Aged 80 and over Radiological and Ultrasound Technology Age Factors Middle Aged medicine.disease Magnetic Resonance Imaging 030104 developmental biology Neurology Hippocampal volume Female Neurology (clinical) Anatomy Older people Cartography 030217 neurology & neurosurgery Mri segmentation |
| Zdroj: | Human Brain Mapping. 39:2500-2513 |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.24017 |
| Popis: | OBJECTIVES: MRI has become an indispensable tool for brain volumetric studies, with the hippocampus an important region of interest. Automation of the MRI segmentation process has helped advance the field by facilitating the volumetric analysis of larger cohorts and more studies. FreeSurfer has emerged as the de facto standard tool for these analyses, but studies validating its output are all based on older versions. To characterize FreeSurfer’s validity, we compare several versions of FreeSurfer software with traditional hand-tracing. EXPERIMENTAL DESIGN: Using MRI images of 262 males and 402 females aged 38 to 84, we directly compare estimates of hippocampal volume from multiple versions of FreeSurfer, its hippocampal subfield routines, and our manual tracing protocol. We then use those estimates to assess asymmetry and atrophy, comparing performance of different estimators with each other and with brain atrophy measures. PRINCIPAL OBSERVATIONS: FreeSurfer consistently reports larger volumes than manual tracing. This difference is smaller in larger hippocampi or older people, with these biases weaker in version 6.0.0 than prior versions. All methods tested agree qualitatively on rightward asymmetry and increasing atrophy in older people. CONCLUSIONS: FreeSurfer saves time and money, and approximates the same atrophy measures as manual tracing, but it introduces biases that could require statistical adjustments in some studies. |
| Databáze: | OpenAIRE |
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