The new topical steroid ciclesonide is effective in the treatment of allergic rhinitis
| Autor: | Wilhelm Wurst, Anette C. Georgens, Martin Wehling, Bernhard Schmidt, Wolfgang Timmer, Monika Hilt, Catherine Mattinger, Karl Hörmann |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Allergy Nasal Provocation Tests Adolescent medicine.medical_treatment Provocation test Anti-Inflammatory Agents Ciclesonide chemistry.chemical_compound Double-Blind Method Pregnenediones Medicine Humans Pharmacology (medical) Administration Intranasal Rhinitis Pharmacology rhinorrhea Cross-Over Studies medicine.diagnostic_test business.industry Pruritus Allergens Middle Aged medicine.disease Crossover study Nasal Mucosa Treatment Outcome chemistry Nasal spray Anesthesia Female medicine.symptom Rhinomanometry Nasal Obstruction business Topical steroid |
| Zdroj: | Journal of clinical pharmacology. 39(10) |
| ISSN: | 0091-2700 |
| Popis: | A randomized, placebo-controlled, double-blind crossover study was performed to investigate the efficacy of ciclesonide nasal spray in allergic rhinitis at the dose level of 200 micrograms per nostril. Twenty-four subjects (13 males, 11 females; median age: 28 years) with a history of allergic rhinitis but free of symptoms at screening entered the study. Ciclesonide and placebo were given for 7 days each with a washout period of at least 14 days in between. In both treatment periods, controlled intranasal allergen provocation with pollen extracts was performed on the 2 days before start of treatment (days -2 and -1) and on all treatment days (days 1 to 7) about 2 hours after administration of the study medication. At 5 and 30 minutes after each allergen provocation, rhinal airflow was measured by anterior rhinomanometry, and the subjective symptoms of obstruction, itching, and rhinorrhea were assessed by means of a standardized visual analog scale. Rhinal airflow improved significantly from day 5, while the subjective symptom of obstruction improved from day 2. Itching and rhinorrhea also improved significantly. The local and systemic tolerability of ciclesonide nasal spray was excellent. The results of this study clearly indicate that the new topical steroid ciclesonide is effective in the treatment of allergic rhinitis without producing local or systemic side effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text