NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats

Autor:	Jana Ruda-Kucerova, Petra Amchová, Filip Šiška, Yousef Tizabi
Rok vydání:	2021
Předmět:	Male Nicotine Kainate receptor Self Administration AMPA receptor Pharmacology Methamphetamine 03 medical and health sciences chemistry.chemical_compound Glutamatergic 0302 clinical medicine Recurrence Quinoxalines Medicine Animals Rats Wistar Receptor Biological Psychiatry Dose-Response Relationship Drug business.industry 030227 psychiatry 3. Good health Rats Psychiatry and Mental health chemistry NBQX business medicine.drug Ionotropic effect
Zdroj:	The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 22(10)
ISSN:	1814-1412
Popis:	Pharmacological manipulations of glutamatergic ionotropic receptors have been suggested as a promising target for addiction treatment. Antagonists of AMPA/kainate receptors were shown to reduce alcohol intake or alcohol-seeking in various animal models. In this study, we evaluated the effect of NBQX, an AMPA/kainate receptor antagonist, on methamphetamine (METH) and nicotine self-administration in rats.Male Wistar rats were trained to self-administer METH (0.08 mg/kg per infusion, session of 90 min) and nicotine (0.03 mg/kg per infusion, session of 60 min) under the fixed ratio 1 schedule of reinforcement. The maintenance training was 2 weeks. During the second week, NBQX was injected subcutaneously at doses of 5 or 10 mg/kg 20 min before the session or intravenously (IV) at doses of 1 and 5 mg/kg 10 min before the session. Following the maintenance training, rats were subjected to forced abstinence for 2 weeks and 1 day of the drug-free relapse-like session with IV NBQX treatment performed as before.Although NBQX did not affect nicotine maintenance, it significantly suppressed the drug-paired responding in the relapse session. Regarding METH, NBQX did not exert a significant effect at either phase of the study.These findings suggest selective involvement of AMPA/kainate receptors in the relapse of nicotine seeking after a period of forced abstinence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f90bec43b15a3e9305a1568b9294336 https://pubmed.ncbi.nlm.nih.gov/33787469 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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