Association between serum folate levels and schizophrenia based on sex

Autor:	Shusuke Numata, Shinya Watanabe, Masahito Nakataki, Tetsuro Ohmori, Yukiko Tomioka, Tomohiko Nakayama, Makoto Kinoshita, Hidehiro Umehara
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty 03 medical and health sciences chemistry.chemical_compound Folic Acid Sex Factors 0302 clinical medicine Serum folate Japan Internal medicine medicine Humans Inverse correlation Homocysteine Pyridoxal Aged Rank correlation Serum folate level business.industry General Neuroscience General Medicine Middle Aged Japanese population medicine.disease Vitamin B 6 030227 psychiatry Psychiatry and Mental health Endocrinology Neurology chemistry Schizophrenia Cohort Female Neurology (clinical) business 030217 neurology & neurosurgery
Zdroj:	Psychiatry and Clinical Neurosciences. 74:466-471
ISSN:	1440-1819 1323-1316
DOI:	10.1111/pcn.13074
Popis:	Aim: Gender differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on gender. In this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by gender. The relationships between serum folate levels, plasma total homocysteine (tHcy) and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies. Methods: The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1,350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on gender. Spearman’s rank correlation was used to evaluate the relationships between folate, tHcy and vitamin B6 levels. Results: In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort. Conclusion: Our findings suggest that (1) a low serum folate level may be associated with schizophrenia regardless of gender, and (2) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels.
Databáze:	OpenAIRE
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