Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
| Autor: | Elizabeth R. Toolan, Patricia I. Dickson, James R. Watson, Parith Wongkittichote, Dorothy K. Grange, Jennifer M. Leonard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Myocarditis lcsh:QH426-470 Endocrinology Diabetes and Metabolism Cardiomyopathy Case Report Case Reports Biochemistry Genetics and Molecular Biology (miscellaneous) Gastroenterology lcsh:Diseases of the endocrine glands. Clinical endocrinology COVID‐19 Internal medicine Internal Medicine medicine LCHAD Beta oxidation lcsh:RC648-665 long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency business.industry Hypoketotic hypoglycemia Refractory hypotension medicine.disease lcsh:Genetics Peripheral neuropathy fatty acid oxidation disorder Vomiting medicine.symptom business Rhabdomyolysis cardiomyopathy |
| Zdroj: | JIMD Reports, Vol 56, Iss 1, Pp 40-45 (2020) JIMD Reports |
| ISSN: | 2192-8312 |
| Popis: | Long‐chain fatty‐acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID‐19) is a pandemic caused by the RNA virus SARS‐CoV‐2 with diverse presentations ranging from respiratory symptoms to myocarditis. We report a case of a patient with LCHADD who initially presented with typical metabolic decompensation symptoms including nausea, vomiting, and rhabdomyolysis in addition to mild cough, and was found to have COVID‐19. She developed acute respiratory failure and refractory hypotension from severe cardiomyopathy which progressed to multiple organ failure and death. Our case illustrates the need for close monitoring of cardiac function in patients with a long‐chain fatty acid oxidation disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text