Conformation and activity in angiotensin II peptides

Autor:	Mahesh C. Khosla, C. Sakarellos, Serge Fermandjian, F. Merlin Bumpus, Karl Lintner, R. R. Smeby, François Piriou
Rok vydání:	1981
Předmět:	Circular dichroism Aqueous solution Protein Conformation Stereochemistry Chemistry Angiotensin II Organic Chemistry Biophysics Blood Pressure General Medicine Biochemistry Biomaterials Structure-Activity Relationship Animals Competitive inhibitor
Zdroj:	Biopolymers. 20:1971-1983
ISSN:	1097-0282 0006-3525
DOI:	10.1002/bip.1981.360200919
Popis:	Angiotensin II and its competitive inhibitor [Sar1, Ile8]-angiotensin II, as well as several analogs of these two compounds specifically chosen for their well-defined pharmacological properties, were studied by circular dichroism and nuclear magnetic resonance methods at various pH values in aqueous solution and in d6-dimethylsulfoxide. The results were compared with their biological activities. This allowed us to establish relationships between conformation and pressor activity, explaining most of the properties of angiotensin II, its inhibitor, and the analogs successively substituted in positions 3 and 5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8e195d8e64b466e51b83c737fe1f51 https://doi.org/10.1002/bip.1981.360200919 Zobrazit plný text záznamu Plný text