Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon
| Autor: | Faruck Lukmanul Hakkim, Prawej Ansari, Rabia Farzand, Naji Abuglela, Ángel Serrano-Aroca, Murtaza M. Tambuwala, Mohamed M. Nasef, Vijay Mishra, Alaa A. A. Aljabali, Hamid A. Bakshi, Gerry A. Quinn |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Colorectal cancer
oral drug delivery gastrointestinal technology gut microflora Pharmaceutical Science Genetically modified bacteria Disease Review Bioinformatics Pharmacy and materia medica gut metabolism Drug Discovery Medicine colon targeted delivery Irritable bowel syndrome colon business.industry Metabolism medicine.disease Ulcerative colitis digestive system diseases RS1-441 Targeted drug delivery probiotics Drug delivery genetically modified bacteria Molecular Medicine business |
| Zdroj: | Pharmaceuticals Pharmaceuticals, Vol 14, Iss 1211, p 1211 (2021) |
| ISSN: | 1424-8247 |
| Popis: | The prevalence of colon-associated diseases has increased significantly over the past several decades, as evidenced by accumulated literature on conditions such as Crohn’s disease, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Developing therapeutics for these diseases is challenging due to physiological barriers of the colon, systemic side effects, and the intestinal environment. Therefore, in a search for novel methods to overcome some of these problems, researchers discovered that microbial metabolism by gut microbiotia offers a potential method for targeted drug delivery This overview highlights several drug delivery systems used to modulate the microbiota and improve colon-targeted drug delivery. This technology will be important in developing a new generation of therapies which harness the metabolism of the human gut microflora. |
| Databáze: | OpenAIRE |
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