Phosphodiesterase-1 inhibitory activity of two flavonoids isolated from pistacia integerrima J. L. Stewart galls
| Autor: | Haroon Khan, Francesco Maione, Abdur Rauf, Muhammad Saleem, Muslim Raza, Ghias Uddin, Ajmal Khan, Vincenzo De Feo, Bina S. Siddiqui, Syeda Zehra Hamid, Nicola Mascolo |
|---|---|
| Přispěvatelé: | Rauf, A, Saleem, M, Uddin, G, Siddiqui, B, Khan, H, Raza, M, Hamid, Sz, Khan, A, Maione, Francesco, Mascolo, NICOLA DOMENICO C. FERDINANDO, De Feo, V. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Naringenin
PULMONARY ARTERIAL-HYPERTENSION Article Subject In silico Biology Pistacia integerrima DISEASE chemistry.chemical_compound CLINICAL-TRIALS ENVIRONMENT DISCOVERY ACID chemistry.chemical_classification Traditional medicine Phosphodiesterase Biological activity lcsh:Other systems of medicine biology.organism_classification lcsh:RZ201-999 In vitro Enzyme Complementary and alternative medicine chemistry Pistacia lentiscus Research Article |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015) Evidence-based Complementary and Alternative Medicine : eCAM |
| Popis: | Pistacia integerrimais one of twenty species among the genusPistacia. Long horn-shaped galls that develop on this plant are harvested and used in Ayurveda and Indian traditional medicine to make “karkatshringi”, a herbal medicine used for the treatment of asthma and different disorders of respiratory tract. However, until now, the molecular mechanisms of action of “karkatshringi” and its chemical characterization are partially known. This study deals with the isolation and characterization of the active constituents from the methanolic extract ofP. integerrimagalls and it was also oriented to evaluatein vitroandin silicotheir potential enzymatic inhibitory activity against phosphodiesterase-1 (PDE1), a well-known enzyme involved in airway smooth muscle activity and airway inflammation. Our results showed that the methanolic extract ofP. integerrimagalls and some of its active constituents [naringenin (1) and 3,5,7,4′-tetrahydroxy-flavanone (2)] are ablein vitroto inhibit PDE1 activity (59.20 ± 4.95%, 75.90 ± 5.90%, and 65.25 ± 5.25%, resp.) and demonstratein silicoan interesting interaction with this enzymatic site. Taken together, our results add new knowledge of chemical constituents responsible for the biological activity ofP. integerrimaand contextually legitimate the use of this plant in folk medicine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|