Antithrombin Ⅲ is a Novel Predictor for Contrast Induced Nephropathy After Coronary Angiography
| Autor: | Chungen Yan, Mingyu Liang, Zeyuan Lu, Yang Zhou, Niansong Wang, Feng Wang, Rui Wu, Rulian Liang, Yiwei Kong, Qing Zhao, Jianyong Yin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system medicine.drug_class Coronary angiography Antithrombin III 030232 urology & nephrology Contrast-induced nephropathy Contrast Media 030204 cardiovascular system & hematology lcsh:RC870-923 Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Contrast induced nephropathy Predictive Value of Tests Internal medicine medicine lcsh:Dermatology Humans Cardiac Surgical Procedures Aged Creatinine business.industry Incidence (epidemiology) Anticoagulant Antithrombin Acute kidney injury General Medicine Guideline Middle Aged lcsh:RL1-803 medicine.disease Prognosis lcsh:Diseases of the genitourinary system. Urology female genital diseases and pregnancy complications Cardiac surgery Cross-Sectional Studies chemistry Nephrology lcsh:RC666-701 Kidney Diseases Cardiology and Cardiovascular Medicine business medicine.drug Predictor |
| Zdroj: | Kidney & Blood Pressure Research, Vol 43, Iss 1, Pp 170-180 (2018) |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Background/Aims: Antithrombin Ⅲ (AT Ⅲ) is an important endogenous anticoagulant and has strong anti-inflammatory properties. Low ATⅢ activity is considered to be a predictor of poor outcomes in several conditions, including acute kidney injury after cardiac surgery. However, the association between the ATⅢ level and the occurrence of contrast induced nephropathy (CIN) has not been elucidated. In this study, our aim was to identify the potential predictive value of ATⅢ for CIN. Methods: We enrolled a total of 460 patients who underwent coronary angiography (CAG) from January 2015 to December 2016 in coronary care units (CCU). ATⅢ activity in plasma collected before CAG was measured and Results: Of these 460 patients undergoing CAG, 125 (27.17%) progressed to CIN. The incidence of CIN was significantly higher in patients with low ATⅢ activity compared to patients with normal ATⅢ activity (Pearson’s chi-squared test P=0.002). As ATⅢ activity declined, the prevalence of CIN progressively increased, with the highest value (58.8%) in patients with an ATⅢ activity Conclusions: Patients with low ATⅢ activity had a higher risk of developing CIN after CAG. The initial ATⅢ activity may be a novel independent predictor for CIN. |
| Databáze: | OpenAIRE |
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