Vascular Endothelial Growth Factor (Vegf) +936 C/T Gene Polymorphisms and Gastric Cancer Risk: A Meta-Analysis Involving 4,138 Subjects
| Autor: | Yong Zhou, Wen Hu, Mao-Ling Wei, Xiao-Ting Wu, Xun Yao, Liang Du, Tai-Xiang Wu, Guan-Jian Liu, Wen Zhuang |
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| Rok vydání: | 2010 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine Cancer Research medicine.medical_specialty Clinical Biochemistry Subgroup analysis Bioinformatics Polymorphism Single Nucleotide Gastroenterology White People Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Asian People Risk Factors Stomach Neoplasms Internal medicine Humans Medicine Genetic Predisposition to Disease Stage (cooking) Genetic Association Studies business.industry Cancer Odds ratio medicine.disease Confidence interval Vascular endothelial growth factor Vascular endothelial growth factor A 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Meta-analysis business |
| Zdroj: | The International Journal of Biological Markers. 25:213-218 |
| ISSN: | 1724-6008 |
| DOI: | 10.5301/jbm.2010.6110 |
| Popis: | The association between vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk is still controversial and ambiguous. The objective of our study was to investigate this association. The Medline and Embase databases were searched by two investigators. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to test the association between VEGF +936 C/T polymorphisms and gastric cancer risk. Our meta-analysis comprised seven case-control studies, which included 1,893 gastric cancer cases and 2,245 controls. The combined results showed that there was no relationship between VEGF +936 C/T gene polymorphisms and gastric cancer risk (cc: OR 0.97, 95% CI 0.85, 1.11; CT: OR 1.01, 95% CI 0.88, 1.16; TT: OR 1.10, 95% CI 0.79, 1.55). Subgroup analysis by ethnicity and stage, location, and Lauren classification of gastric cancer did not change the results. This meta-analysis suggests that there is no association between VEGF +936 C/T polymorphisms and gastric cancer risk. Further studies should pay attention to other potentially functional SNPs. |
| Databáze: | OpenAIRE |
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