MR-guided transcranial brain HIFU in small animal models
| Autor: | Mathias Fink, E. Dervishi, Benoit Larrat, Jean-François Aubry, Anne-Laure Boch, Mathieu Pernot, Yannick Marie, Danielle Seilhean, Ralph Sinkus, Mickael Tanter |
|---|---|
| Přispěvatelé: | Physique des ondes pour la médecine, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Biologie des Interactions Neurones / Glie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Service de neuro-pathologie [CHU Pitié-Salpêtrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Neurochirurgie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Pernot, Mathieu |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
Ultrasonic Therapy MESH: Elasticity Imaging Techniques 030218 nuclear medicine & medical imaging MESH: Magnetic Resonance Imaging Elasticity Imaging Techniques 0302 clinical medicine Edema rat MESH: Animals Magnetic resonance Elastography MESH: Turkeys MESH: Muscle Skeletal Radiological and Ultrasound Technology medicine.diagnostic_test Ultrasound Temperature Brain Magnetic Resonance Thermometry MESH: Ultrasonic Therapy MESH: Thermometers Magnetic Resonance Imaging MESH: Temperature MESH: Edema Databases as Topic [SDV.IB]Life Sciences [q-bio]/Bioengineering High Intensity Focused Ultrasound MESH: Pressure Mri guided Algorithms medicine.medical_specialty Turkeys Monitoring MESH: Rats Thermometers MESH: Motion Models Neurological MESH: Algorithms Article 03 medical and health sciences MESH: Brain Motion Necrosis In vivo MESH: Models Neurological Small animal medicine Radiation Force Localization Pressure Animals Radiology Nuclear Medicine and imaging Acoustic radiation force Muscle Skeletal [SDV.IB] Life Sciences [q-bio]/Bioengineering MESH: Necrosis business.industry Magnetic resonance imaging Acoustics Elasticity Magnetic resonance elastography Rats MESH: Acoustics MESH: Elasticity Feasibility Studies business MESH: Feasibility Studies MESH: Databases as Topic 030217 neurology & neurosurgery transcranial Biomedical engineering |
| Zdroj: | Physics in Medicine and Biology Physics in Medicine and Biology, 2010, 55 (2), pp.365-88. ⟨10.1088/0031-9155/55/2/003⟩ Physics in Medicine and Biology, IOP Publishing, 2010, 55 (2), pp.365-88. ⟨10.1088/0031-9155/55/2/003⟩ |
| ISSN: | 0031-9155 1361-6560 |
| DOI: | 10.1088/0031-9155/55/2/003⟩ |
| Popis: | International audience; Recent studies have demonstrated the feasibility of transcranial high-intensity focused ultrasound (HIFU) therapy in the brain using adaptive focusing techniques. However, the complexity of the procedures imposes provision of accurate targeting, monitoring and control of this emerging therapeutic modality in order to ensure the safety of the treatment and avoid potential damaging effects of ultrasound on healthy tissues. For these purposes, a complete workflow and setup for HIFU treatment under magnetic resonance (MR) guidance is proposed and implemented in rats. For the first time, tissue displacements induced by the acoustic radiation force are detected in vivo in brain tissues and measured quantitatively using motion-sensitive MR sequences. Such a valuable target control prior to treatment assesses the quality of the focusing pattern in situ and enables us to estimate the acoustic intensity at focus. This MR-acoustic radiation force imaging is then correlated with conventional MR-thermometry sequences which are used to follow the temperature changes during the HIFU therapeutic session. Last, pre- and post-treatment magnetic resonance elastography (MRE) datasets are acquired and evaluated as a new potential way to non-invasively control the stiffness changes due to the presence of thermal necrosis. As a proof of concept, MR-guided HIFU is performed in vitro in turkey breast samples and in vivo in transcranial rat brain experiments. The experiments are conducted using a dedicated MR-compatible HIFU setup in a high-field MRI scanner (7 T). Results obtained on rats confirmed that both the MR localization of the US focal point and the pre- and post-HIFU measurement of the tissue stiffness, together with temperature control during HIFU are feasible and valuable techniques for efficient monitoring of HIFU in the brain. Brain elasticity appears to be more sensitive to the presence of oedema than to tissue necrosis. |
| Databáze: | OpenAIRE |
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