Engineered systems to study the synergistic signaling between integrin-mediated mechanotransduction and growth factors (Review)
| Autor: | A Isabela Monteiro, Tarek Kollmetz, Jenny Malmström |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell signaling Integrins medicine.medical_treatment Integrin General Physics and Astronomy Models Biological General Biochemistry Genetics and Molecular Biology Cell Physiological Phenomena Biomaterials 03 medical and health sciences Tissue engineering medicine General Materials Science Patient treatment Mechanotransduction biology Growth factor General Chemistry Stem-cell therapy 030104 developmental biology biology.protein Intercellular Signaling Peptides and Proteins Signal transduction Neuroscience Signal Transduction |
| Zdroj: | Biointerphases. 13(6) |
| ISSN: | 1559-4106 |
| Popis: | While tremendous leaps in knowledge into cellular signaling and control have been achieved over the last few decades, there is still more to learn in how different signaling pathways act synergistically. A better understanding and control of cells in vitro and in vivo is important to enable more successful and safe applications of tissue engineering and stem cell therapy. This review is focused on two central ways cells sense their surroundings, namely, integrin-mediated mechanotransduction and growth factor signaling. Specifically, the authors explore how engineered interfaces have been applied to learn more about these processes, and how these important signaling pathways interact synergistically. |
| Databáze: | OpenAIRE |
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