Structured illumination ophthalmoscope: super-resolution microscopy on the living human eye
| Autor: | Florian Schock, Gerrit Best, Nil Celik, Rainer Heintzmann, Stefan Dithmar, Christoph Cremer |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 380 |
| ISSN: | 1471-2962 1364-503X |
| DOI: | 10.1098/rsta.2021.0151 |
| Popis: | In this paper, we present the prototype of an ophthalmoscope that uses structured illumination microscopy (SIM) to enable super-resolved imaging of the human retina, and give first insights into clinical application possibilities. The SIM technique was applied to build a prototype that uses the lens of the human eye as an objective to ‘super-resolve’ the retina of a living human. In our multidisciplinary collaboration, we have adapted this well-established technique in ophthalmology and successfully imaged a human retina using significantly lower light intensity than a state-of-the-art ophthalmoscope. Here, we focus on the technical implementation and highlight future perspectives of this method. A more application-oriented note for physicians on the diagnostic and disease-preventive value of this method, as well as the medical results of the clinical study carried out, will be published in a report addressed to an appropriate specialist audience. This article is part of the Theo Murphy meeting issue ‘Super-resolution structured illumination microscopy (part 2)’. |
| Databáze: | OpenAIRE |
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