Direct-acting antivirals for hepatitis C virus induce a rapid clinical and biochemical remission of porphyria cutanea tarda
| Autor: | Andrea Combalia, M. Martínez‐Rebollar, Paula Aguilera, Jordi To-Figueras, Montserrat Laguno |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Porphyria Cutanea Tarda congenital hereditary and neonatal diseases and abnormalities Hepatitis C virus Population Dermatology DIRECT ACTING ANTIVIRALS medicine.disease_cause Antiviral Agents Poor adherence 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine Humans Porphyria cutanea tarda education Aged High rate education.field_of_study Porphyria business.industry Remission Induction Off-Label Use Phlebotomy Hepatitis C Chronic Middle Aged bacterial infections and mycoses medicine.disease Hepatitis C Porfíria Treatment Outcome Cohort Immunology 030211 gastroenterology & hepatology Female Dermatologic Agents business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1365-2133 |
| Popis: | Sporadic porphyria cutanea tarda (PCT) is strongly associated with HCV infection in our population 1,2,3,4. . Therapeutic options for PCT include phlebotomies and low-dose 4-aminoquinolines, which show high rates of disease remission. However, some PCT patients may present frequent relapses attributable to resistance/intolerability/poor adherence to conventional treatments and/or persistence of risk factors. In 2014 we reported the first case of a patient with active PCT and HCV-HIV co-infection cured with direct antiviral agents (DAAs) 5. Herein, we present a larger cohort of patients, demonstrating the rapid and persistent remission of PCT with DAAs regimes administered for HVC infection. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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