The role of IL-1β in aortic aneurysm
| Autor: | Jiang Zhi-sheng, Oware Kwabena Agyare, Zhao Simin, Qu Shunlin, Tang Tingting, Zeng Qian, Wan Hengquan, Fan Wenjing |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Inflammasomes medicine.drug_class medicine.medical_treatment Interleukin-1beta Clinical Biochemistry Inflammation Bioinformatics Biochemistry 03 medical and health sciences Aortic aneurysm 0302 clinical medicine Immune system medicine Humans Receptor business.industry Caspase 1 Biochemistry (medical) General Medicine medicine.disease Receptor antagonist Hedgehog signaling pathway Aortic Aneurysm 030104 developmental biology Cytokine Mechanism of action 030220 oncology & carcinogenesis Cytokines medicine.symptom business |
| Zdroj: | Clinica Chimica Acta. 504:7-14 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2020.01.007 |
| Popis: | Interleukin-1β (IL-1β) is a vital cytokine that plays an important role in regulating immune responses to infectious challenges and sterile insults. In addition, two endogenous inhibitors of functional receptor binding, IL-1 receptor antagonist (IL-1Ra), complete the family. To gain biological activity, IL-1β requires processing by the protease caspase-1 and activation of inflammasomes. Numerous clinical association studies and experimental approaches have implicated members of the IL-1 family, their receptors, or components of the processing machinery in the underlying processes of cardiovascular diseases. Here, we summarize the current state of knowledge regarding the pro-inflammatory and disease-modulating role of the IL-1 family in aneurysm. We discuss clinical evidence, signalling pathway, and mechanism of action and last, lend a perspective on currently developing therapeutic strategies involving IL-1β in aneurysm. |
| Databáze: | OpenAIRE |
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