Arterial wall hypoxia following hyperfusion through the vasa vasorum is an initial lesion in atherosclerosis
| Autor: | J. F. Martin, S. Moncada, R. F. G. Booth |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Arteriosclerosis medicine.medical_treatment Clinical Biochemistry Sterol O-acyltransferase Ischemia Biochemistry Muscle Smooth Vascular Internal medicine Occlusion medicine Animals RNA Messenger Hypoxia Platelet-Derived Growth Factor Cell growth business.industry Growth factor Vasa Vasorum Thrombosis General Medicine Arteries Hypoxia (medical) medicine.disease Disease Models Animal medicine.anatomical_structure Cholesterol Vasa vasorum Cardiology Rabbits medicine.symptom business |
| Zdroj: | European journal of clinical investigation. 20(6) |
| ISSN: | 0014-2972 |
| Popis: | Pressure on the outside of arteries can cause physical and biochemical changes in the vessel wall of rabbits which are characteristic of atherosclerosis. It is hypothesized that occlusion of the vasa vasorum causes ischaemia of the arterial media which results in smooth muscle cell proliferation and cellular accumulation of cholesteryl esters. Hypoxia increases mRNA for platelet-derived growth factor in arterial wall cells and increases the activity of acyl CoA: cholesterol acyltransferase (ACAT). Such a mechanism may explain many of the anatomical, actuarial and environmental risk factors for atherosclerosis. Hyperfusion of the vasa vasorum may follow thrombosis. |
| Databáze: | OpenAIRE |
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