Clinical value of a [18F]-FDG PET-CT muscle-to-muscle SUV ratio for the diagnosis of active dermatomyositis
| Autor: | Anne-Sophie Morin, Aurélie Grados, Benoit Brihaye, Éric Denis, Olivier Lidove, Thierry Zenone, Yoland Schoindre, Fanny Andry, Benjamin Terrier, Alexandra Audemard, Nihal Martis, Emeline Castela, Denis Quinsat, Mikael Ebbo, Nicolas Mounier, Stéphane Liguori, Laurent Marcq, Philippe Viau, Jean-Philippe Chaborel |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Sensitivity and Specificity Dermatomyositis 030218 nuclear medicine & medical imaging 03 medical and health sciences Visual grading 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Muscle Skeletal Aged Retrospective Studies Aged 80 and over Muscle biopsy medicine.diagnostic_test business.industry Ultrasound Reproducibility of Results General Medicine Middle Aged medicine.disease Control subjects Positron emission tomography 030220 oncology & carcinogenesis Clinical value Female Fdg pet ct Radiology Radiopharmaceuticals business Nuclear medicine |
| Zdroj: | European Radiology. 29:6708-6716 |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-019-06302-9 |
| Popis: | To study a muscle-to-muscle standardised uptake value (SUV) ratio with FDG-PET/CT (FDG-PET) as a marker for the detection of disease activity in dermatomyositis (DM). Patients with DM (n = 24) who met the European Neuro-Muscular Centre diagnostic criteria were retrospectively identified over a 3-year period through a national survey. Muscle biopsy was performed in all patients. Maximum SUV was measured in proximal muscles (SUVPROX) that had the highest radiotracer uptake on visual grading as well as in the musculus longissimus thoracis (SUVMLT), whereas mean SUV was measured for the liver (SUVLIV). Muscle-to-liver SUV ratios for either muscle group were compared and a SUVPROX/SUVMLT ratio was calculated. SUVPROX/SUVMLT of DM patients were compared with age- and sex-matched control subjects (n = 24) with melanoma who had received FDG-PET scans. DM patients presented with proximal and symmetrical muscle uptake. Differences in SUVPROX/SUVLIV and SUVMLT/SUVLIV ratios in DM subjects were significant (p |
| Databáze: | OpenAIRE |
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