Comparison of regional cerebral blood flow in patients with anorexia nervosa before and after weight gain
| Autor: | Akinori Masuda, Nobuatshu Nagai, Masayuki Nakajo, Shin-ichi Nozoe, Yoshiaki Nakabeppu, Shinya Kojima, Tetsuro Naruo, Tetsuro Muranaga, Daisuke Deguchi |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Cingulate cortex medicine.medical_specialty Anorexia Nervosa Adolescent Neuroscience (miscellaneous) Hemodynamics Single-photon emission computed tomography Weight Gain Gyrus Cinguli Severity of Illness Index Functional Laterality Internal medicine mental disorders medicine Humans Radiology Nuclear Medicine and imaging Anterior cingulate cortex Tomography Emission-Computed Single-Photon medicine.diagnostic_test Brain Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Endocrinology medicine.anatomical_structure nervous system Cerebral blood flow Regional Blood Flow Anorexia nervosa (differential diagnoses) Cardiology Female medicine.symptom Psychology Body mass index Weight gain psychological phenomena and processes |
| Zdroj: | Psychiatry Research: Neuroimaging. 140:251-258 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2005.08.002 |
| Popis: | We investigated changes in regional cerebral blood flow (rCBF) before and after weight gain in patients with restrictive anorexia nervosa (AN-R) in comparison with findings in normal subjects. We assessed resting rCBF using single photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime in 12 AN-R patients and 11 controls. Each patient was examined at two time points, at the beginning of treatment and after weight gain (average examination interval=88+/-26 days). Control subjects were examined only once. Before treatment, the AN-R group had lower rCBF in the bilateral anterior lobes, including the anterior cingulate cortex (ACC), and in the right parietal lobe, the insula, and the occipital lobes. After weight gain, the patients showed significant increases in the right parietal lobe and decreases in the basal ganglia and cerebellum in accordance with significant improvement in body weight and eating attitudes. However, they showed persistent decreases in the ACC area even after weight gain compared with findings in the controls. A significant positive correlation was observed between body mass index and rCBF in the occipital lobes in the patients. These results suggest that weight gain is associated with a normalization of rCBF in a number of brain areas, but that the low level of rCBF in the ACC at baseline is unaffected by treatment in AN-R. |
| Databáze: | OpenAIRE |
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