Cross-cultural study of a biochemical abnormality in paranoid schizophrenia
| Autor: | Richard Jed Wyatt, Sheth As, Farouk Karoum, Steven G. Potkin, Shobha Thatte, Dinsha R. Doongaji, Apte Js, Dilip V. Jeste, Dilkhush Panjwani, M. Datta |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Cross-Cultural Comparison Male Paranoid schizophrenia medicine.medical_specialty Urinary system India Urine chemistry.chemical_compound Urinary excretion Internal medicine Phenethylamines mental disorders medicine Humans Psychiatry Biological Psychiatry Psychiatric Status Rating Scales Creatinine Schizophrenia Paranoid food and beverages medicine.disease Psychiatry and Mental health chemistry Schizophrenia Female Schizophrenic Psychology Abnormality Psychology Urine collection |
| Zdroj: | Psychiatry Research. 5:341-352 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/0165-1781(81)90082-2 |
| Popis: | We studied 24-hour urinary excretion of phenylethylamine (PEA) and creatinine in 50 schizophrenic (39 paranoid and 11 nonparanoid) and 19 nonpsychiatric patients from Bombay, India. Methods for diagnosis, clinical assessment, and 24-hour urine collection were identical to those used in an earlier study done in a Washington, D.C. hospital. Clinical evaluations were done in Bombay, while urinary PEA and creatinine estimations were performed at NIMH, Washington, without knowledge of the subjects' identity. Paranoid schizophrenic patients had significantly greater 24-hour urinary excretion of PEA than both nonparanoid schizophrenic patients and nonpsychiatric controls. The mean amount of PEA per g creatinine in urine was also highest for paranoid schizophrenic patients. Our findings provide cross-cultural support to the possibility of abnormal PEA metabolism in at least some patients with paranoid schizophrenia. |
| Databáze: | OpenAIRE |
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