Body mass index and risk of infections: a Mendelian randomization study of 101,447 individuals
| Autor: | Tine Jess, Kristine H. Allin, Shoaib Afzal, Børge G. Nordestgaard, Matilde Winter-Jensen |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Epidemiology 030204 cardiovascular system & hematology Skin infection Infections Body Mass Index Sepsis 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Mendelian randomization medicine Humans 030212 general & internal medicine Obesity Proportional hazards model business.industry Confounding Odds ratio Pneumonia Mendelian Randomization Analysis medicine.disease Causality Population study Female business Body mass index |
| Zdroj: | European journal of epidemiology. 35(4) |
| ISSN: | 1573-7284 |
| Popis: | Body mass index (BMI) has been related to risk of infections. The aim of this study was to assess the shape of the association between BMI and risk of infections and to evaluate whether such associations represent causality. We included 101,447 individuals from The Copenhagen General Population Study who had BMI measured. Outcome was hospital contacts related to infections. The shape of the association between BMI and risk of infections was examined using restricted cubic spline Cox regression. To evaluate causality, we used Mendelian randomization, an epidemiological method that counteracts confounding and reverse causality by using genetic variation as instrumental variables. We created a genetic risk score based on five genetic variants causing lifelong higher BMI and used this score in instrumental variable analysis. During median follow-up of 8.8 years, 10,263 hospital contacts related to infections were recorded. We found a U-shaped association between BMI and risk of any infection and pneumonia, and a linear association between BMI and risk of skin infection, urinary tract infection, and sepsis. In instrumental variable analyses, higher BMI was associated with increased risk of skin infection: odds ratio 1.12 (95% CI 1.03–1.22) for a genetically induced 1 unit increase in BMI. Observationally, low as well as high BMI was associated with increased risk of any infection and pneumonia, whereas only high BMI was associated with increased risk of skin infection, urinary tract infection, and sepsis. High BMI was causally associated with increased risk of skin infection. |
| Databáze: | OpenAIRE |
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