The effects of nicardipine or esmolol on the onset time of rocuronium and intubation conditions during rapid sequence induction: a randomized double-blind trial
| Autor: | Kye Hyeok Lee, Yunkwang Kim, Cheong Lee, Ji-Yeon Lee, Ji Heui Lee, Sung Kyu Rim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Methyl Ethers medicine.medical_treatment Adrenergic beta-Antagonists Nicardipine Blood Pressure Anesthesia General Sevoflurane Propanolamines Double-Blind Method Heart Rate Intubation Intratracheal medicine Humans Intubation Androstanols Rocuronium business.industry Tracheal intubation Middle Aged Rapid sequence induction Esmolol Anesthesiology and Pain Medicine Anesthesia Female Onset of action business medicine.drug |
| Zdroj: | Journal of Anesthesia. 29:403-408 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s00540-014-1940-5 |
| Popis: | The main aims of rapid sequence induction (RSI) are prompt and adequate muscle relaxation for tracheal intubation and hemodynamic stability during and after intubation. The purpose of the present study was to investigate the effects of nicardipine and esmolol on the action of rocuronium and intubation conditions during RSI. Adult patients (n = 82) were randomly allocated to one of three groups. One minute prior to the induction of sevoflurane-based general anesthesia, patients received 20 μg/kg of nicardipine (N group; n = 27) or 0.5 mg/kg of esmolol (E group; n = 27), or 5 ml of saline (C group; n = 28). Patients were assessed according to intubation conditions, the onset time of rocuronium, mean arterial pressure (MAP), and heart rate (HR) during RSI. The intubation conditions and score were significantly better in the C and N groups than in the E group (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink