Assessment at 6 months may be warranted for patients with chronic myeloid leukemia with no major cytogenetic response at 3 months
| Autor: | Alfonso Quintás-Cardama, Lynne V. Abruzzo, Raja Luthra, Hagop M. Kantarjian, Elias Jabbour, Jorge E. Cortes, Sherry Pierce, Carlos Guillermo Romo, Farhad Ravandi, Preetesh Jain, Aziz Nazha, Gautam Borthakur, Susan O'Brien |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Time Factors Myeloid Adolescent Chronic Myeloid Leukemia Young Adult Internal medicine medicine Humans Young adult Protein Kinase Inhibitors Survival rate Aged Aged 80 and over business.industry Myeloid leukemia Imatinib Hematology Middle Aged medicine.disease Survival Rate Leukemia Treatment Outcome medicine.anatomical_structure Cytogenetic Analysis Leukemia Myeloid Chronic-Phase Immunology Female Major Cytogenetic Response business Tyrosine kinase Follow-Up Studies medicine.drug |
| Zdroj: | Haematologica. 98:1686-1688 |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.2013.090282 |
| Popis: | Response to tyrosine kinase inhibitors at three months is a predictor for long-term outcome in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. We analyzed 456 newly diagnosed chronic myeloid leukemia patients treated with tyrosine kinase inhibitors to determine their outcome based on their response at six months. Forty-four (10%) patients did not achieve major cytogenetic response at three months: 18 of 67 (27%) patients treated with imatinib 400; 18 of 196 (9%) with imatinib 800; and 8 of 193 (4%) with 2nd generation tyrosine kinase inhibitors. Among them, 19 (43%) achieved major cytogenetic response at six months and subsequently had an overall outcome similar to the patients who achieved a major cytogenetic response at three months. In conclusion, the response to tyrosine kinase inhibitors at three months is a static, one-time measure. Assessing the response at six months of patients with poor response at three months may provide a better predictor for long-term outcome. |
| Databáze: | OpenAIRE |
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