Angiogenesis and the tumour hypoxia response in prostate cancer: a review
| Autor: | R. Kaba, Prasanna Sooriakumaran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty Prostate cancer business.industry Angiogenesis General Medicine Hypoxia (medical) medicine.disease Metastasis Vascular endothelial growth factor Management of prostate cancer chemistry.chemical_compound HIF1A medicine.anatomical_structure chemistry Prostate Internal medicine medicine Surgery medicine.symptom Hypoxia business |
| DOI: | 10.1016/j.ijsu.2005.03.013 |
| Popis: | The formation of new blood vessels, angiogenesis, is a highly-regulated active process that is critical for the development of the normal and malignant prostate. The vascular endothelial growth factor (VEGF) system assumes a critical role in the angiogenic process. Angiogenesis is a prerequisite for the expansion of solid tumours beyond 1–3mm 3 and is stimulated in response to a hypoxic environment. This review discusses the process of angiogenesis and the key angiogenic mediator, VEGF, and their role in tumour progression and metastasis. A better understanding of the mechanisms behind angiogenesis will ultimately lead to the development of new anti-angiogenic agents in the management of prostate cancer. |
| Databáze: | OpenAIRE |
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