Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

Autor:	Walter Cabri, Antonio Ricci, Andrea Orlandin, Francesco Gasparrini, Alberto Foschini, Omar H. Ismail, Simone Manetto, Martina Catani, Giulia Mazzoccanti, Alberto Cavazzini, Michele Bassan
Přispěvatelé:	Mazzoccanti G., Manetto S., Bassan M., Foschini A., Orlandin A., Ricci A., Cabri W., Ismail O.H., Catani M., Cavazzini A., Gasparrini F.
Rok vydání:	2020
Předmět:	Chemical substance dynamic electrostatic-repulsion reversed-phase General Chemical Engineering Peptide 010402 general chemistry 01 natural sciences peptides HPLC NO peptide epimers UHPLC Related impurities Basic peptides Basic amino acids Reversed phase chemistry.chemical_classification Chromatography Chemistry Electrostatic repulsion 010401 analytical chemistry Analytical tool General Chemistry Electrostatics Therapeutic peptides 0104 chemical sciences Analytical tool Basic amino acids Basic peptides Electrostatic repulsion Related impurities Reversed phase Therapeutic peptides Isobaric process
Zdroj:	RSC Advances. 10:12604-12610
ISSN:	2046-2069
DOI:	10.1039/d0ra01296c
Popis:	The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f743f1ad118086b4096fe7dbe5d1baa https://doi.org/10.1039/d0ra01296c Zobrazit plný text záznamu