Immunoglobulin levels during follow-up of children with selective IgA deficiency
| Autor: | P. C. J. De Laat, Jan A.J.M. Bakkeren, Corry M.R. Weemaes |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Saliva Immunoglobulin levels Adolescent Immunology Immunoglobulins Selective IgA deficiency Immunoglobulin E Immunoglobulin D Subclass medicine Humans Longitudinal Studies Child biology business.industry IgA Deficiency Infant General Medicine medicine.disease Immunoglobulin A El Niño Immunoglobulin M Child Preschool Immunoglobulin G Immunoglobulin A Secretory biology.protein Female Dysgammaglobulinemia Antibody business Follow-Up Studies |
| Zdroj: | Scandinavian journal of immunology. 35(6) |
| ISSN: | 0300-9475 |
| Popis: | Longitudinal serum immunoglobulin levels were studied in 36 children with selective IgA deficiency during a median follow-up period of 5 years. Twenty-live children were "sporadic' cases, and 11 were "familiar. Serum and saliva IgA levels in 23 children remained below 2 mg/'l. Eight children with IgA levels above 2 mg/1 showed considerahle intra-individual variance in serum IgA. but remained IgA deficient. Five children at various ages developed IgA levels above 50mg/l with detectable secretory IgA in saliva- In most of the children IgG subclass levels were found to be rather high, including at younger ages. There were no obvious differences between 'sporadie' and 'familial' eases except an assoeiation between IgD deficiency and serum IgA levels below 2 mg/1, and between serum levels of IgD above 1 ItJ/ml and of IgA above 2 mg/1, which was found to be significant in the "sporadic' group but not in the "familial' group. |
| Databáze: | OpenAIRE |
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