Imipenem Resistance in a Salmonella Clinical Strain Due to Plasmid-Mediated Class A Carbapenemase KPC-2
| Autor: | Shannon Rossiter, Eva Tzelepi, Vivi Miriagou, Leonidas S. Tzouvelekis, Frederick J. Angulo, Jean M. Whichard |
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| Rok vydání: | 2003 |
| Předmět: |
Serotype
Salmonella Imipenem Klebsiella pneumoniae Molecular Sequence Data Microbial Sensitivity Tests Drug resistance medicine.disease_cause beta-Lactamases Microbiology Plasmid Bacterial Proteins Mechanisms of Resistance Drug Resistance Bacterial polycyclic compounds medicine Humans Pharmacology (medical) Cloning Molecular Antibacterial agent Pharmacology Base Sequence biology biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Virology Infectious Diseases Salmonella enterica Conjugation Genetic Plasmids medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 47:1297-1300 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.47.4.1297-1300.2003 |
| Popis: | A Salmonella enterica serotype Cubana isolate exhibiting resistance to most β-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. β-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of bla KPC-2 with mobile structures. |
| Databáze: | OpenAIRE |
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