Controlled Delivery of Nitric Oxide for Cancer Therapy
| Autor: | Khaled Greish, Allan B. Gamble, Houman Alimoradi, Gregory I. Giles |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Tumor targeting
Cancer therapy Biomedical Engineering Pharmaceutical Science Antineoplastic Agents Controlled delivery Nitric oxide donors 02 engineering and technology Article Nitric oxide 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems Immune system Neoplasms Humans Medicine Cytotoxicity 030304 developmental biology Drug Carriers 0303 health sciences business.industry Nitric oxide releasing biomaterials Cancer 021001 nanoscience & nanotechnology medicine.disease chemistry Cancer research Nanoparticles 0210 nano-technology Wound healing business |
| Zdroj: | Pharmaceutical Nanotechnology |
| ISSN: | 2211-7385 |
| Popis: | Nitric oxide (NO) is a short-lived, endogenously produced, signaling molecule which plays multiple roles in mammalian physiology. Underproduction of NO is associated with several pathological processes; hence a broad range of NO donors have emerged as potential therapeutics for cardiovascular and respiratory disorders, wound healing, the immune response to infection, and cancer. However, short half-lives, chemical reactivity, rapid systemic clearance, and cytotoxicity have hindered the clinical development of most low molecular weight NO donors. Hence, for controlled NO delivery, there has been extensive effort to design novel NO-releasing biomaterials for tumor targeting. This review covers the effects of NO in cancer biology, NO releasing moieties which can be used for NO delivery, and current advances in the design of NO releasing biomaterials focusing on their applications for tumor therapy. |
| Databáze: | OpenAIRE |
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