Incomplete Fibrin Formation and Highly Elevated Factor XIII Activity in Multiple Myeloma
| Autor: | K Havemann, R. Egbring, H G Klingemann |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Immunodiffusion
medicine.medical_specialty Paraproteinemias Immunoglobulins Hemorrhage Fibrin Casein Internal medicine medicine Humans Multiple myeloma Blood coagulation test Factor XIII biology Chemistry Hematology medicine.disease Fibrin Monomer Endocrinology Immunology biology.protein Electrophoresis Polyacrylamide Gel Blood Coagulation Tests Paraproteins Multiple Myeloma Complication medicine.drug |
| Zdroj: | Scandinavian Journal of Haematology. 27:253-262 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1981.tb00481.x |
| Popis: | Bleeding is a common complication in patients suffering from multiple myeloma. In some cases a defect in fibrin formation has been suggested as one possible cause of haemorrhagic tendency. As shown in this investigation the defect in fibrin formation, ascertained using PAGE, is due to a lack of alpha-chain polymerization of fibrin monomers in 5/11 patients with IgG myeloma and in 2/5 patients with IgM paraproteinaemia. No disturbed fibrin polymerization could be observed in IgA myeloma (n = 6). Factor XIII concentrations of subunit A and to a lesser extent of subunit S (Laurell technique) were highly elevated in all cases with regular fibrin formation. comparable values were obtained by measuring the transamidase activity of factor XIII by incorporation of 14C-labelled purtrescin into casein. Levels up to 600% of normal could be recorded. In contrast, all patients with a lack of alpha-chain polymerization had a factor XIII activity within the normal range. Addition of factor XIII concentrate to plasma from patients with defective fibrin formation led in 5/8 cases to a partial cross-linking of alpha-monomers. we conclude that in some cases paraproteins can inhibit the factor XIII and prevent its action on fibrin. |
| Databáze: | OpenAIRE |
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