Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case study
| Autor: | Wendy Tanamai, Bruce J. Tromberg, David Hsiang, Cynthia Chen, Albert E. Cerussi, John Butler, Sara Siavoshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty media_common.quotation_subject Biopsy Biomedical Engineering Breast Neoplasms Article metabolism pathology [Breast] Biomaterials methods [Spectroscopy Near-Infrared] Hemoglobins Young Adult Breast cancer In vivo medicine Medicine and Health Sciences analysis [Lipids] Mammography Humans Breast Spectroscopy Menstrual cycle media_common Wound Healing Spectroscopy Near-Infrared medicine.diagnostic_test business.industry analysis [Water] Cancer Water medicine.disease Fibroadenoma Lipids Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials pathology [Breast Neoplasms] Female analysis [Hemoglobins] Nuclear medicine business |
| Zdroj: | Tanamai, Wendy; Chen, Cynthia; Siavoshi, Sara; Cerussi, Albert; Hsiang, David; Butler, John; et al.(2009). Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case study.. Journal of biomedical optics, 14(1), 014024-0140014024. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/9xn5h4hj |
| Popis: | Diffuse optical spectroscopy (DOS) has been used to monitor and predict the effects of neoadjuvant (i.e., presurgical) chemotherapy in breast cancer patients in several pilot studies. Because patients with suspected breast cancers undergo biopsy prior to treatment, it is important to understand how biopsy trauma influences DOS measurements in the breast. The goal of this study was to measure the effects of a standard core breast biopsy on DOS measurements of tissue deoxyhemoglobin, hemoglobin, water, and bulk lipid concentrations. We serially monitored postbiopsy effects in the breast tissue in a single subject (31-year-old premenopausal female) with a 37x18x20 mm fibroadenoma. A baseline measurement and eight weekly postbiopsy measurements were taken with a handheld DOS imaging instrument. Our instrument used frequency domain photon migration combined with broadband steady-state spectroscopy to characterize tissues via quantitative measurements of tissue absorption and reduced scattering coefficients from 650 to 1000 nm. The concentrations of significant near-infrared (NIR) absorbers were mapped within a 50 cm(2) area over the biopsied region. A 2-D image of a contrast function called the tissue optical index (TOI=deoxyhemoglobinxwaterbulk lipid) was generated and revealed that a minimum of 14 days postbiopsy was required to return TOI levels in the biopsied area to their prebiopsy levels. Changes in the TOI images of the fibroadenoma also reflected the progression of the patient's menstrual cycle. DOS could therefore be useful in evaluating both wound-healing response and the effects of hormone and hormonal therapies in vivo. |
| Databáze: | OpenAIRE |
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