Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine

Autor:	Reza Rahbarghazi, Emel Sokullu, Aysa Rezabakhsh
Přispěvatelé:	Sokullu, Emel (ORCID 0000-0003-1302-1997 & YÖK ID 163024), Rezabakhsh, Aysa, Rahbarghazi Reza, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Medicine (General) Challenging Disadvantages Exosomes Regenerative medicine Whole-cell therapy Medicine (miscellaneous) Economic shortage QD415-436 Biochemistry Genetics and Molecular Biology (miscellaneous) Extracellular vesicles Biochemistry Paracrine signalling Extracellular Vesicles Viewpoint R5-920 Medicine Cell biology Research and experimental medicine Cell and tissue engineering Ethical issues business.industry Stem Cells Mesenchymal stem cell fungi Mesenchymal Stem Cells Cell Biology Microvesicles Molecular Medicine Stem cell business Neuroscience
Zdroj:	Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-8 (2021) Stem Cell Research & Therapy Stem Cell Research and Therapy
ISSN:	1757-6512
Popis:	Recent advances in the identification and application of different stem cell types have offered alternative therapeutic approaches for clinicians. The lack of successful engraftment, migration into the injured site, loss of functionality and viability, ethical issues, shortage of donated allogeneic stem cells and the possibility of transmission of infectious are the main challenges associated with direct cell transplantation. The discovery and research on exosomes have led to the rise of hopes for the alleviation of different pathologies in regenerative medicine. Exo are nano-sized extracellular vesicles (40–150 nm) and released by each type. These nanoparticles participate in cell-to-cell communication in a paracrine manner. It is thought that the application of Exo can circumvent several drawbacks related to whole-cell therapies. Because of their appropriate size and stability, Exo are touted as therapeutic bullets transferring signaling factors into the acceptor cells in a paracrine manner. Despite these advantages, technologies associated with Exo isolation and purification are challenging because of heterogeneity in exosomal size and cargo. The lack of standard GMP-grade protocols is the main hurdle that limits the extensive application of Exo in the clinical setting. Here, the authors aimed to inspire a logical and realistic vision about problems associated with Exo application in regenerative medicine. Tabriz University of Medical Sciences; National Institute for Medical Research Development
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6f60377797ca6da1a572220265f9f4 https://doaj.org/article/720bea941df34a02aaeec9e1700e8007 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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