Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement
Autor: | Richard Schwab, Mihaly Kollar, László Kopper, Diana Brauswetter, Helga Barti-Juhasz, Edit Várkondi, Júlia Schönléber, Andrea Kohanka, Ferenc Pinter, István Peták, Laszlo Urban |
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Rok vydání: | 2014 |
Předmět: |
Male
Pulmonary and Respiratory Medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms C-Met Pyridines medicine.drug_class medicine.medical_treatment medicine.disease_cause Targeted therapy chemistry.chemical_compound Crizotinib Internal medicine Carcinoma medicine ROS1 Humans Pericarditis Anaplastic Lymphoma Kinase Protein Kinase Inhibitors Aged Neoplasm Staging EGFR inhibitors Gene Rearrangement Radiotherapy business.industry Gene Amplification Receptor Protein-Tyrosine Kinases Proto-Oncogene Proteins c-met medicine.disease Tumor Burden ALK inhibitor chemistry Mutation Carcinoma Squamous Cell Pyrazoles Radiography Thoracic KRAS business medicine.drug |
Zdroj: | Lung Cancer. 83:109-111 |
ISSN: | 0169-5002 |
DOI: | 10.1016/j.lungcan.2013.10.006 |
Popis: | The initial radiotherapy of a 73 years old Caucasian male patient with advanced squamous cell lung carcinoma was terminated due to severe pericarditis. Subsequently, the tumor sample was analyzed for possible targets with comprehensive molecular diagnostics. EGFR, KRAS and PIK3CA genes were wild type, ALK and ROS1 were negative for rearrangement, but c-MET was amplified by fluorescent in situ hybridization. The kinase inhibitor crizotinib is already in clinical use for the treatment of ALK positive non-small cell lung cancers, but it is also known to be a potent c-MET inhibitor. The patient was treated with the standard dose of twice a day 250 mg crizotinib as a monotherapy. Major partial response to therapy was confirmed by chest CT and PET/CT after 8 weeks on therapy. C-MET expression is associated with poor prognosis and resistance to EGFR inhibitors. This case may indicate that c-MET tyrosine kinase inhibitors can be an effective targeted treatment option for squamous cell carcinoma patients, and future clinical trials should be expanded for this patient group as well. |
Databáze: | OpenAIRE |
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