Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress
| Autor: | Snezana B Pajovic, Nataša Popović, Ljubica Gavrilović, Vesna Stojikjkovic, Snezana Pejic, Ivan Pavlović, Ana Todorović |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Restraint Physical 0301 basic medicine acute stress medicine.medical_specialty Antioxidant medicine.medical_treatment Cell Redox Antioxidants Gene Expression Regulation Enzymologic General Biochemistry Genetics and Molecular Biology brain cortex Superoxide dismutase 03 medical and health sciences Superoxide Dismutase-1 0302 clinical medicine Stress Physiological Internal medicine medicine Animals Chronic stress Rats Wistar Swimming chronic stress Cerebral Cortex chemistry.chemical_classification reactive oxygen species Reactive oxygen species biology Superoxide Dismutase Chemistry General Medicine Catalase Rats Cold Temperature 030104 developmental biology medicine.anatomical_structure Enzyme Endocrinology Biochemistry biology.protein Antioxidant enzymes 030217 neurology & neurosurgery |
| Zdroj: | Folia Biologica (Krakow) |
| Popis: | The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases. |
| Databáze: | OpenAIRE |
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