Effect of RMI-12,936 on fertilization and egg transport in the rabbit
| Autor: | R. Salmonsen, I.F. Lau, Shiva K. Saksena |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Ovulation
Medroxyprogesterone medicine.medical_specialty Time Factors media_common.quotation_subject Uterus Medroxyprogesterone Acetate Biology Chorionic Gonadotropin Ovum Transport Subcutaneous injection Human fertilization Estrus Pregnancy Internal medicine medicine Animals Medroxyprogesterone acetate Testosterone Progesterone media_common Estrous cycle Androstenols Abortifacient Agents Steroidal Obstetrics and Gynecology medicine.disease 20-alpha-Dihydroprogesterone medicine.anatomical_structure Endocrinology Reproductive Medicine Fertilization Testosterone enanthate Female Rabbits medicine.drug |
| Zdroj: | Contraception. 24:107-116 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/0010-7824(81)90073-1 |
| Popis: | The effect of a single subcutaneous injection of 10 mg/kg, 17β-hydroxy-7α-methylandrost-5-en-3-one (RMI-12,936) on ovulation, fertilization and egg transport in rabbits was studied. In vehicle-treated estrous does 24 hr after the ovulation stimulus, all fertilized eggs were recovered from the oviducts. Whereas administration of RMI-12,936, 1 day before ovulation, did not affect the fertilization or the egg transport but the number of unruptured follicles was significantly increased (3.3% in control vs. 25% in RMI-12,936-treated does). When RMI-12,936 was given 3 days before ovulation, a premature expulsion of eggs into the uterus within 24 hr of ovulation was recorded. In addition, there was an increase in the number of unruptured follicles and only 41.9 percent of the ovulated eggs were recovered. Circulating progesterone ( Δ 4 P), 20α-dihydroprogesterone (20α-DHP) and testosterone (T) concentrations monitored over a period of 24 hr after ovulation stimulus in RMI-12,936-treated does resulted in a significant increase in serum T. A suppression in Δ 4 P and 20α-DHP one day after RMI-12,936 treatment was evident. In contrast, hCG failed to alter the Δ 4 P and 20α-DHP levels in those does treated 3 days before with RMI-12,936. When RMI-12,936 results on egg transport were compared with those obtained from does treated with medroxyprogesterone acetate (MPA) or testosterone enanthate (TE), a reduction in the rate of egg recovery and an increase in the number of unruptured follicles in MPA-treated does were observed. It is concluded that RMI-12,936, if given before ovulation, can interrupt pregnancy by accelerating the egg transport without affecting the fertilization. |
| Databáze: | OpenAIRE |
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