Oncolytic virotherapy for pediatric malignancies: future prospects
| Autor: | Gregory K. Friedman, Alicia M. Waters, Elizabeth A. Beierle, Eric Ring |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty viruses Review Disease reovirus medicine.disease_cause Virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Virotherapy vaccinia oncolytic virus 030304 developmental biology 0303 health sciences business.industry herpes simplex virus Seneca Valley virus 3. Good health Oncolytic virus Clinical trial Herpes simplex virus chemistry 030220 oncology & carcinogenesis Immunology Vaccinia business |
| Zdroj: | Oncolytic Virotherapy |
| ISSN: | 2253-1572 |
| Popis: | Pediatric solid tumors remain a major health concern, with nearly 16,000 children diagnosed each year. Of those, ~2,000 succumb to their disease, and survivors often suffer from lifelong disability secondary to toxic effects of current treatments. Countless multimodality treatment regimens are being explored to make advances against this deadly disease. One targeted treatment approach is oncolytic virotherapy. Conditionally replicating viruses can infect tumor cells while leaving normal cells unharmed. Four viruses have been advanced to pediatric clinical trials, including herpes simplex virus-1, Seneca Valley virus, reovirus, and vaccinia virus. In this review, we discuss the mechanism of action of each virus, pediatric preclinical studies conducted to date, past and ongoing pediatric clinical trials, and potential future direction for these novel viral therapeutics. |
| Databáze: | OpenAIRE |
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