Vasopressin responses to asphyxia and hemorrhage in newborn pigs
| Autor: | Charles W. Leffler, David W. Busija, D. G. Beasley, D. P. Brooks, Anthony M. Fletcher, Leonard Share, Joan T. Crofton |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Cardiac output Vasopressin Swine Physiology Partial Pressure Indomethacin Lypressin Blood Pressure Hemorrhage Peptide hormone Asphyxia Physiology (medical) Internal medicine medicine Animals Lysine vasopressin Meclofenamic Acid biology business.industry Co2 partial pressure Carbon Dioxide Hydrogen-Ion Concentration Oxygen Endocrinology Blood pressure Animals Newborn Anesthesia biology.protein Cyclooxygenase medicine.symptom business |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 252:R122-R126 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | Vasopressin may be important in maintenance of arterial pressure and redistribution of cardiac output in hypotensive and asphyxiated newborns. We used chronically instrumented, unanesthetized, 4-day-old pigs to investigate the effects of hypotensive hemorrhage and asphyxia on plasma vasopressin concentration and to determine the effects of cyclooxygenase inhibition on these responses. Asphyxia [arterial O2 partial pressure (PaO2) = 40-50 Torr, arterial CO2 partial pressure (PaCO2) = 60-80 Torr) increases plasma lysine vasopressin (LVP) from 2.2 +/- 0.8 to 52.4 +/- 15.0 microU/ml. Neither the baseline nor stimulated plasma LVP was affected by indomethacin (5 mg/kg) or meclofenamate (5 mg/kg). Hemorrhage (30 ml/kg) increased plasma LVP from 2.8 +/- 0.8 to 163.4 +/- 28.1 (20 min) and 135.1 +/- 18.5 microU/ml (60 min). The effects of vehicle and indomethacin (5 mg/kg) 20 min after hemorrhage on plasma LVP 60 min after hemorrhage were not different. Changes in plasma vasopressin caused by asphyxia and hemorrhage in the unanesthetized newborn pig are similar to the responses observed in adults of other species. This study does not suggest that prostanoids are involved in these responses in newborn pigs. |
| Databáze: | OpenAIRE |
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