Morphometric analysis of the lung in prolonged bronchopulmonary dysplasia
| Autor: | R E Sobonya, M M Logvinoff, Lynn M. Taussig, A Theriault |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pulmonary Heart Disease Airway abnormalities Medicine Humans Lung Bronchopulmonary Dysplasia Heart Failure Respiratory distress business.industry Myocardium Infant Newborn respiratory system medicine.disease respiratory tract diseases Pulmonary Alveoli medicine.anatomical_structure Morphometric analysis Bronchopulmonary dysplasia Ventricle Child Preschool Pediatrics Perinatology and Child Health Oxygen dependency business Airway |
| Zdroj: | Pediatric research. 16(11) |
| ISSN: | 0031-3998 |
| Popis: | Summary: Morphometric analysis of the lungs and heart of a male infant who died at 33 months of age of bronchopulmonary dysplasia after prematurity and respiratory distress syndrome and its treatment is presented. Alveolar internal surface area was 8.4 m2 compared to 15.3–27.8 for age-matched controls. The number of alveoli was 19 X 106 (123.3–172.5 X 106 for controls); however, the mean small airway diameter, 0.44 mm was normal, and small airway abnormalities were minimal. There was marked muscular hypertrophy of the right ventricle. Speculation: Severe neonatal lung injury, with persistent oxygen dependency throughout infancy might result in inhibition or marked slowing of lung growth. Because development of conducting airways is completed early during intrauterine life and because most alveolar development takes place postnatally, one might expect disturbances in alveolar growth to overshadow residual airway injury in survivors of bronchopulmonary dysplasia. |
| Databáze: | OpenAIRE |
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