Body mass index-associated differences in response to ovulation induction with letrozole
| Autor: | Victoria R. Chapman, G.W. Bates, Katherine McKnight, James L. Nodler, John J. Cooper, Suzanne P. Cliver |
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| Rok vydání: | 2011 |
| Předmět: |
Infertility
Adult Ovulation medicine.medical_specialty Pregnancy Rate Reproductive endocrinology and infertility medicine.medical_treatment media_common.quotation_subject Body Mass Index Ovulation Induction Pregnancy Nitriles medicine Odds Ratio Humans Obesity Menstrual cycle Insemination Artificial media_common Retrospective Studies Gynecology Chi-Square Distribution business.industry Obstetrics Aromatase Inhibitors Letrozole Ovary Obstetrics and Gynecology Retrospective cohort study Fertility Agents Female Triazoles medicine.disease Logistic Models Treatment Outcome Reproductive Medicine Alabama Ovulation induction Female business Body mass index Infertility Female medicine.drug |
| Zdroj: | Fertility and sterility. 96(5) |
| ISSN: | 1556-5653 |
| Popis: | To compare occurrence of pregnancy among obese (body mass index [BMI] ≥30) and nonobese (BMI30), infertile women undergoing ovulation induction with the aromatase inhibitor letrozole followed by intrauterine insemination (IUI).Retrospective cohort study.Academic reproductive endocrinology and infertility clinic.Ninety women with a variety of infertility diagnoses.Letrozole (5 mg) on menstrual cycle days 3-7, followed by intrauterine insemination (IUI).Occurrence of pregnancy and pregnancy outcomes.Ninety women underwent 180 letrozole-IUI cycles. Conception of pregnancy occurred in 10.4% and 18.2% of the BMI30 and BMI ≥30 groups, respectively. Using BMI as a continuous variable showed a pregnancy odds ratio of 1.093 (confidence interval 1.008-1.184) for each unit increase in BMI. Incidence of miscarriage, multiple births, number of mature follicles, and presence of LH surge were similar between groups.Our study of 90 women undergoing letrozole-IUI treatment showed greater likelihood of pregnancy in higher-BMI women, although the difference was not significant. Letrozole is an effective ovulation induction agent in higher-BMI women. |
| Databáze: | OpenAIRE |
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