Hematologic abnormalities following renal transplantation
| Autor: | Mark A. Marinella |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Nephrology
medicine.medical_specialty Pancytopenia Urology Population Lymphoproliferative disorders Context (language use) Polycythemia Malignancy Lymphohistiocytosis Hemophagocytic Internal medicine medicine Humans Intensive care medicine education Kidney transplantation education.field_of_study Thrombotic Microangiopathies business.industry Anemia Leukopenia medicine.disease Hematologic Diseases Kidney Transplantation Transplantation surgical procedures operative Hematologic Neoplasms business |
| Zdroj: | International Urology and Nephrology. 42:151-164 |
| ISSN: | 1573-2584 0301-1623 |
| DOI: | 10.1007/s11255-009-9558-5 |
| Popis: | Recipients of renal allografts are surviving longer and, consequently, may experience a variety of complications related not only to the transplanted kidney, but also to the hematopoietic system. Common hematologic complications in the renal transplant patient include abnormalities of one cell line, such as post-transplantation erythrocytosis or anemia, that are often treatable with simple measures. Conversely, pathologies involving the leukocyte and platelet population often exist in the context of pancytopenia, which may be a manifestation of systemic infection (e.g., cytomegalovirus, human herpesvirus 8) or malignancy (post-transplantation lymphoproliferative disorders). Uncommon, but life-threatening, processes complicating renal transplantation include hepatosplenic gammadelta T-cell lymphoma and viral-induced hemophagocytic syndrome, both of which are associated with severe pancytopenia and, often, death. Since this patient population is often managed in a multidisciplinary fashion by nephrologists, infection specialists, transplant surgeons, hematologists, and internal medicine physicians, a succinct review of this topic is warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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