Cytology in Nipple Aspirate Fluid During a Randomized Soy Food Intervention Among Premenopausal Women

Autor:	Shana Suzuki, Gertraud Maskarinec, Hormoz Ehya, Adrian A. Franke, Ian Pagano, Yukiko Morimoto
Rok vydání:	2013
Předmět:	Adult Cancer Research medicine.medical_specialty media_common.quotation_subject Medicine (miscellaneous) Physiology Washout period Article Nipple Aspirate Fluid Cytology Humans Medicine Breast Menstrual cycle media_common Gynecology Cross-Over Studies Nutrition and Dietetics Breast tissue business.industry Soy Foods Epithelial Cells Middle Aged Crossover study Intervention studies Diet Premenopause Oncology Soy food Female business
Zdroj:	Nutrition and Cancer. 65:1116-1121
ISSN:	1532-7914 0163-5581
DOI:	10.1080/01635581.2013.833638
Popis:	Because soy food consumption may influence breast tissue activity, we examined its effect on the presence of epithelial cells in nipple aspirate fluid (NAF). In a randomized, crossover design, 82 premenopausal women completed a high-soy and a low-soy diet for 6 months each, separated by a 1-month washout period. They provided NAF samples at baseline, 6 months, and 13 months during the midluteal phase of the menstrual cycle. Papanicolaou-stained cytology slides (for 33 women at baseline, 24 at low-soy, and 36 at high-soy) were evaluated in women with sufficient NAF. Mixed models evaluated the effect of the high-soy diet on epithelial cytology as compared to baseline and the low-soy diet. At the end of the high-soy diet, cytological class had decreased in 8 (24%) and increased in 3 (9%) women as compared to baseline, whereas the respective values were 3 (14%) and 6 (29%) for the low-soy diet samples (p=0.32). Only the change in subclass indicated a trend in lower cytological class (p=0.06). Contrary to an earlier report, the number of NAF samples with hyperplastic epithelial cells did not increase after a soy intervention in amounts consumed by Asians.
Databáze:	OpenAIRE
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