Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines
| Autor: | Bhanu P. Pappu, Pornpimon Angkasekwinai, Chen Dong |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Inflammation
Biology medicine.disease_cause Article Autoimmunity chemistry.chemical_compound Mice Interleukin 20 Immune system medicine Parasitic Diseases Animals Humans Pharmacology (medical) Pharmacology Interleukin-17 NFAT NF-κB Cell Differentiation T-Lymphocytes Helper-Inducer Asthma chemistry Immunology Tumor necrosis factor alpha Interleukin 17 medicine.symptom Signal Transduction |
| Zdroj: | Pharmacologytherapeutics. 117(3) |
| ISSN: | 0163-7258 |
| Popis: | Interleukin 17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play critical function in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses. Here we summarize recent work by us as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases. |
| Databáze: | OpenAIRE |
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